ABSTRACT
This study was designed to evaluate the cytohistomorphological and biochemical effect of alcoholic beverages on the prostate gland of adult male Wistar rats. Sixty-five (65) rats weighing between 180-230g were used for this experiment. They were randomly divided into 13 groups of five (5) animals each. Group 1 was the normal control. Group 2-13 were the experiment groups. Group 2, 3 and 4 were treated with 1.23mg/kg, 2.45mg/kg and 3.68mg/kg bodyweight of brandy respectively. Group 5, 6 and 7 were treated with 17.32mg/kg, 34.64mg/ kg and 51.96mg/kg body weight of beer respectively. Group 8, 9 and 10 were treated with 12.25mg/kg, 24.96mg/kg and 36.74mg/kg bodyweight of soured wine respectively. Group 11, 12 and 13 were treated with 1.73mg/kg, 3.46mg/kg and 5.20mg/kg bodyweight of dry gin respectively. Administration was done daily for 28 days and orally using orogastric tube. On the 29th day, the animals were sacrificed using chloroform inhalation anaesthesia. The blood samples were aspirated via cardiac puncture and centrifuged for biochemical analysis, and testicular tissues were harvested, fixed in 10% buffered formalin, processed, and stained with haematoxylin and eosin. Body weight showed significant (p<0.05) increase in brandy administered groups compared to control. For testicular weight, there was an insignificant increase in all the treated groups except the group administered with 3.69mg/kg which showed insignificant decrease compared to control. Results for TT showed a general significant (p<0.001) decrease in all administered groups compared to control. FSH showed significant (p<0.05;0.01;0.001) decrease in group administered 3.69mg/kg of brandy, all administered groups of soured wine and group administered 5.20mg/kg of dry gin compared to control. Histology showed narrowed and elongated lumen of seminiferous tubule, hypertrophied sertoli cells, destroyed interstitial cells of leydig, distorted seminiferous tubules with degenerating spermatogenic cells in the administered groups compared to control. In conclusion, alcohol beverages pose adverse effects on the testes.